Pharmacogenomics and lung transplantation: clinical implications
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics and Opioid Analgesics: Clinical Implications
Variation exists in patient response on analgesic treatment in terms of efficacy and safety. This variation may be in part explained by pharmacogenomics. This paper aimed to review data on pharmacogenomics of opioid analgesics focusing on the effect of genetic variation on the efficacy and safety of these agents. Current evidence suggests that pharmacogenomics contribute to variation in efficac...
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Despite advances and investments in translation research, clinical trials and health service in general, there is no significant impact on the survival of most patients diagnosed with advanced pancreatic adenocarcinoma. It is broadly recognized though that there is a small minority of patients who really benefit from particular treatments for reason usually not well understood. Light to this fa...
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Anesthetic challenges regarding lung transplantation are related to the expanded spectrum of diseases for which lung transplantation is offered and to the interval changes in health status likely to occur as patients wait longer for an organ to become available. Particular attention to avoiding or reducing the impact of increases in pulmonary vascular resistance and right heart failure are impo...
متن کاملA European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is inco...
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BACKGROUND Pain can be a significant burden for patients with cancer and may have negative effects on their quality of life. Opioids are potent analgesics and serve as a foundation for pain management. The variation in response to opioid analgesics is well characterized and is partly due to genetic variability. METHODS We reviewed the results of clinical studies to evaluate the relationships ...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2006
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500376